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Topiramate (Topamax®) Interactions
Topiramate Drug Interactions: Topiramate has minimal hepatic drug interactions. Inhibits carbonic anhydrase, CYP2C19 (weak). Induces CYP3A4 (weak).
Can you take Topiramate and Alprazolam (Xanax®)? There are no reported drug interactions between topiramate and alprazolam 1. No special precautions appear to be necessary during concomitant use. Can you take Topiramate and Amitriptyline? Generally, concomitant use of topiramate and amitriptyline is safe. Amitriptyline and topiramate combination may be beneficial for patients with migraine and comorbid depression 9 and help to reduce the dosage of amitriptyline. Can you take Topiramate and Aripiprazole (Abilify®)? There are no drug interactions between topiramate and aripiprazole 1. Taking topiramate and aripiprazole together is safe. Their concomitant is use not associated with increased side effects 11. Can you take Topiramate and Diazepam (Valium®)? There are no reported drug interactions between topiramate and diazepam 1. There is evidence that topiramate may potentiates the antiseizure activity diazepam 4. Can you take Topiramate and Excedrin® (Acetaminophen/Aspirin/Caffeine)? Topiramate does not interfere with the active components in Excedrin® -- acetaminophen, aspirin, and caffeine 1. Can you take Topiramate and Ibuprofen (Advil®)? No drug interactions 1. Topiramate can be taken with Ibuprofen at the same time. Can you take Topiramate and Lamotrigine (Lamictal®)? There are no pharmacokinetic interactions between topiramate and lamotrigine 6. Lamotrigine has no effect on topiramate levels 5. Can you take Topiramate and Nortriptyline (Pamelor®)? Due to the lack of interaction between topiramate and nortriptyline the concurrent use of both drugs is safe 1. The combination topiramate with nortriptyline is useful for migraine prevention 12. Can you take Topiramate and Rizatriptan (Maxalt®)? No drug interactions 1. Topiramate prophylactic therapy does not affect the efficacy or safety of rizatriptan for acute migraine relief 7. Can you take Topiramate and Propranolol? Topiramate and propranolol don't interfere with each other 1 and can be used at the same time. Propranolol, a nonselective beta-blocker, is sometimes used in combination with topiramate to reduce migraine headache frequency 10. Can you take Topiramate and Sertraline (Zoloft®)? There are no drug interactions between topiramate and sertraline 1. Combination topiramate with sertraline is effective for binge-eating disorder 3. Can you take Topiramate and Tramadol? The combined use is considered safe. Topiramate label does not warn about concurrent use with tramadol 1. Experimental studies indicate that combination tramadol plus topiramate acts synergistically and may be very effective for the relief of neuropathic pain 2. Topiramate during Pregnancy Pregnancy Category D. An increased risk of cleft lip and cleft palate (oral clefts) has been observed in infants born to women treated with topiramate (Topamax) during pregnancy. Nursing Mothers
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