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Bupropion (Wellbutrin®) InteractionsTaking Bupropion with:
Bupropion Drug interactions
Can you take Bupropion and benzodiazepines at the same time? Bupropion is contraindicated during the abrupt withdrawal from the benzodiazepines because of increased risk of seizures. However, concomitant use of bupropion and benzodiazepines, e.g. alprazolam (Xanax®), diazepam (Valium®), lorazepam (Ativan®), clonazepam (Klonopin®), temazepam (Restoril®), is not contraindicated 1. So bupropion can be taken along with benzodiazepines, but with great caution and under a doctor's supervision. Can you take Bupropion and Adderall® (amphetamine/dextroamphetamine) at the same time? No contraindications/warnings regarding concomitant use 1. Can you take Bupropion and Methylphenidate (Ritalin®, Concerta®) at the same time? Concurrent use of bupropion and methylphenidate is not contraindicated. There are two reports that describe grand mal seizures in one patient 5 and myocardial infarction in another 6, which were associated with the concurrent use of bupropion and methylphenidate. Can you take Bupropion and Phentermine together? No contraindications/warnings regarding concomitant use of bupropion and phentermine 1. Can you take Bupropion with Escitalopram (Lexapro®)? Bupropion can be taken along with escitalopram, but this combination should be used with caution. The combination of escitalopram and bupropion SR may be an effective and well tolerated treatment for major depression 7. Can you take Bupropion with Fluoxetine (Proxac®)? Bupropion can be taken along with fluoxetine 9, but this combination should be used with caution and dosage reduction may be needed. Can you take Bupropion with Paroxetine (Paxil®)? Bupropion can be taken along with paroxetine 9, but this combination should be used with caution and dosage reduction may be needed. Can you take Bupropion with Sertraline (Zoloft®)? Bupropion can be taken along with sertraline 12, but this combination should be used with caution. Can you take Bupropion with Mirtazapine (Remeron®)? Concomitant use is not contraindicated. The combination of bupropion plus mirtazapine is well tolerated and effective 8. Can you take Bupropion with Duloxetine (Cymbalta®)? Concomitant use is not contraindicated. The combination of bupropion plus duloxetine is sometimes used for treatment-resistant depression 13. Can you take Bupropion with Tramadol (Ultram®)? Simultaneous use of bupropion and tramadol may lower the convulsive threshold. Use cautionly. Can you take Bupropion with Aripiprazole (Abilify®)? Concomitant use is not contraindicated. In certain cases aripiprazole is used as adjunctive to bupropion in the treatment of depression 11. Can you take Bupropion and Lorcaserin (Belviq®) at the same time? Theoretical potential for serotonin syndrome. No contraindications regarding concomitant use of bupropion and lorcaserin 10. Can you take Bupropion with Varenicline (Champix®) at the same time? Concomitant use is not contraindiated. Both Bupropion and Varenicline are approved for smoking cessation. These medications work in different ways. Combination treatment with varenicline and bupropion has been proved to be acceptable and effective14. Bupropion during Pregnancy & Lactation Pregnancy category C One study has been conducted in pregnant women. This retrospective, managed-care database study assessed the risk of congenital malformations overall, and cardiovascular malformations specifically, following exposure to bupropion in the first trimester compared to the risk of these malformations following exposure to other antidepressants in the first trimester and bupropion outside of the first trimester. The study showed no greater risk for congenital malformations overall, or cardiovascular malformations specifically, following first trimester bupropion exposure compared to exposure to all other antidepressants in the first trimester, or bupropion outside of the first trimester. The results of this study have not been corroborated. Nursing mothers When Bupropion (Wellbutrin) is a good choice? Those who experience cravings, excessive eating, attention deficit hyperactivity disorder (ADHD), low libido, orgasm dysfunction 2, lethargy, or lack of motivation 3 may benefit from bupropion. It is a worthy choice if tobacco cessation or weight loss is a secondary goal. It may help to overcome retarded depression, depression with coexisting cognitive slowing or pseudo-dementia. When you should not take Bupropion (Wellbutrin)? Bupropion is not a prescription of choice for excessively activated and agitated persons, those who use any other bupropion-containing product (ie, coadministration of Zyban for smoking cessation and Wellbutrin for depression). It is contraindicated for those who have:
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