Citalopram (Celexa®) Interactions
Taking Citalopram with:
Citalopram Drug Interactions:
Citalopram has a relatively low potential for interactions. It is a weak inhibitor of liver cytochrome P450 enzymes.
Adding bupropion to SSRI antidepressant has been a common practice when the SSRI alone does not sufficiently relieve depression. Citalopram and bupropion can be used at the same time 2. One study found that bupropion modestly increases citalopram levels 3.
Possible risk of serotonin syndrome. Nevertheless, citalopram can be used along with opioid analgesics (e.g. hydrocodone, oxycodone, morphine) safely and effectively. The incidence of serotonin syndrome reactions with opioids and SSRIs is fairly rare.
Both medications have a serotonergic action. Tramadol should be used with caution with citalopram because of the increased risk of seizures and serotonin syndrome. The lowest effective dose of tramadol should be used.
Combining more than one SSRI is unusual, and would be expected to increase the risk of side effects. There is very little data on combining SSRIs.
Generally, no clinically significant interaction appears to occur between citalopram and the benzodiazepines 4 (e.g. alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), clonazepam (Klonopin), temazepam (Restoril)) or related medications such zolpidem (Ambien) or zaleplon (Sonata). Sedation may be increased.
No contraindications on concomitant use of citalopram and phentermine 1.
No contraindications on concomitant use of citalopram and methylphenidate 1. The combination of citalopram and methylphenidate has been investigated to accelerate antidepressant response to citalopram 5.
Citalopram can be taken The combination of citalopram and quetiapine has been investigated to accelerate antidepressant response to citalopram 6.
There are no drug interactions between citalopram and topiramate. Limited data suggests that addition of topiramate to citalopram may be useful for treating Compulsive-Impulsive Sexual Behaviors 7.
When you should NOT take Citalopram?
Contraindications for Citalopram use:
Citalopram during Pregnancy & Lactation:
Some animal studies show adverse effects on embryo/fetal and postnatal development. There are no controlled studies in pregnant women and so far has not been proven to be harmful to the fetus. Not generally recommended for use during pregnancy, especially during first trimester.
Citalopram is excreted in human breast milk. If child becomes irritable or sedated, breast feeding or citalopram may need to be discontinued.