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Sertraline (Zoloft®) Interactions
Can you take Sertraline and Adderall®? There are no reported drug interactions between sertraline and amphetamines, the active ingredients of Adderall®1. Can you take Sertraline and Phentermine? Concomitant use of sertraline and phentermine is acceptable. There are no major drug interactions between these medications1. Can you take Sertraline and Alprazolam (Xanax®)? Generally, concomitant use of sertraline and alprazolam is safe. Sertraline does not affect the pharmacokinetics of alprazolam and does not potentiate the psychomotor side effects of alprazolam2, 3. Can you take Sertraline and Lorazepam (Ativan®)? There are no reported drug interaction between sertraline and lorazepam1. Can you take Sertraline and Diazepam (Valium®)? Sertraline has minimal effect on the pharmacokinetic of diazepam4. Generally, concurrent use is safe. Can you take Sertraline and Zolpidem (Ambien®)? No major drug interaction between sertraline and zolpidem1. However, sertraline may slightly shorten onset of action and increase effect of zolpidem11. Can you take Sertraline and Melatonin? Sertraline label does not provide any warnings/precautions regarding concurrent use of sertraline with melatonin1. One case report describes toxic optic neuropathy after concomitant use of melatonin, sertraline, and a high-protein diet6. Can you take Sertraline and Amitriptyline? Both the sertraline and amitriptyline affect serotonin transmission, and concomitant use may result in increased serotonin levels and serotonin syndrome1. Caution is required when sertraline is taken with amitriptyline. Can you take Sertraline and Trazodone? Sertraline label does not warn about concomitant use with trazodone1. Low-dose trazodone is used for insomnia caused by SSRI antidepressants7. Can you take Sertraline and Quetiapine (Seroquel®)? Concurrent use is sertraline and quetiapine safe1. Quetiapine is often added to antidepressant therapy to help manage depression, obsessive-compulsive disorder, and other disorders5. Can you take Sertraline and Tramadol? Both sertraline and tramadol are serotonergic agents and when used together may contribute to serotonin syndrome 1, 8. Taking sertraline and trazodone at the same time is possible but caution should be undertaken. Can you take Sertraline with Oxycodone, Codeine, or Methadone? Risk of serotonin syndrome 1, 9. Sertraline may increase blood levels of methadone 10. Concomitant use of sertraline with opioid analgesics (e.g. oxycodone, codeine, methadone, hydrocodone) is possible under the supervision of a doctor. Can you take Sertraline and Ibuprofen (Advil®)? In most cases taking sertraline and ibuprofen at the same time would not cause problems. Theoretically combination of an SSRI antidepressant with NSAID may potentiate the risk of gastrointestinal or other bleeding1. See also References:
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