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Sumatriptan (Imitrex) Interactions


Can you take Imitrex with Naproxen for migraine?

Combining sumatriptan and naproxen (Aleve) is an established practice. According to the research, sumatriptan 85 mg and naproxen 500 mg combo (Treximet) is better than either of them alone for migraine. Specifically, peak levels for this combination are higher than those reached with sumatriptan alone, and the half-life of naproxen is extended with the combination.

Can you take Imitrex with Acetaminophen?

There are no interactions between sumatriptan and acetaminophen[1]. So it is safe to take Imitrex and acetaminophen (Tylenol) together.

Can you take Imitrex and Ibuprofen?

There are no interactions between sumatriptan and ibuprofen[1]. So it is safe to take Imitrex and ibuprofen (Advil, Motrin) together.

Can you take Imitrex and Cetirizine?

There are no interactions between sumatriptan and antihistamines, including cetirizine (Zyrtec), loratadine (Claritin) and diphenhydramine (Benadryl).

Imitrex and antidepressants

Risk of serotonin syndrome.

The combination of sumatriptan with antidepressants (fluoxetine, paroxetine, sertraline, citalopram, escitalopram, venlafaxine, duloxetine) is not safe and should be taken with caution when indicated 2. As both sumatriptan and antidepressants increase serotonin transmission, the combination can lead to serotonin syndrome.

Imitrex and anticonvulsants

There are no interactions between sumatriptan and anticonvulsants such as topiramate (Topamax), pregabalin (Lyrica), and lamotrigine (Lamictal) 3.

Significant Interactions:

  • Concurrent or recent (within 2 weeks) use of MAO-A inhibitors.
  • Intake within previous 24 hours of ergotamine preparations or another triptan. Ergotamine should not be used within 6 hours after using sumatriptan. The combination may be strongly vasospastic.

References:

  • 1. U.S. FDA Imitrex Prescribing Information.
  • 2. Gardner DM, Lynd LD. Sumatriptan and the serotonin syndrome. Ann Pharmacother. 1998 Jan;32(1):33-8.
  • 3. Bialer M, Doose DR, Murthy B, Curtin C, Wang SS, Twyman RE, Schwabe S. Pharmacokinetic interactions of topiramate. Clin Pharmacokinet. 2004;43(12):763-80. PubMed

By HealthyStock Research Group, March 23, 2012
Medical resources reviewed: August 2018


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