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Gabapentin (Neurontin®) Interactions
Gabapentin Drug Interactions Gabapentin is not appreciably metabolized and does not interfere with other medications. Test Interactions: False positives have been reported with the Ames N-Multistix SG dipstick test for urine protein. Alcohol: There are no known interactions between gabapentin and alcohol. Gabapentin does not alter the effects of alcohol14. Can you take Gabapentin and Alprazolam (Xanax®)? There are no drug interactions between gabapentin and alprazolam as well as other benzodiazepines 1. Can you take Gabapentin and Amitriptyline (Elavil ®)? There are no drug interactions between gabapentin and amitriptyline 1. Amitriptyline with gabapentin combination is used for various types of chronic pain and is more effective than amitriptyline alone 6. Can you take Gabapentin and Baclofen (Lioresal®)? Gabapentin label does not provide any warnings regarding concurrent use with baclofen1. Experimental data suggests that gabapentin may potentiate baclofen-induced motor impairment10. Can you take Gabapentin and Cyclobenzaprine (Flexeril®)? Gabapentin and cyclobenzaprine can be used in conjunction. The concomitant use of these drugs is not expected to be harmful. Some people may experience increased dizziness or drowsiness. Can you take Gabapentin and Hydrocodone, Morphine or other opioids? There are no major drug interactions between gabapentin and opioids (e.g. hydrocodone, oxycodone, morphine) 1. There is evidence that gabapentin can enhance the analgesic effects of morphine and other opioids 7. Morphine can increase the plasma levels of gabapentin1. Can you take Gabapentin with Ibuprofen (Advil®) or other NSAIDs? Gabapentin can be taken along with ibuprofen or other NSAIDs. There are no drug interactions between gabapentin and NSAIDs (e.g. naproxen, ketoprofen, diclofenac, meloxicam) 1. Research data suggests that gabapentin plus naproxen can interact synergistically in the treatment of persistent inflammatory pain 9. Gabapentin plus diclofenac combination is also a promising treatment approach 2. Can you take Gabapentin and Pregabalyn (Lyrica®)? The manufacturer of Lyrica ® notes that there is no pharmacokinetic interaction between pregabalin and gabapentin3. Can you take Gabapentin and Suboxone® (Buprenorphine/Naloxone)? Gabapentin may potentiate the effect of buprenorphine/naloxone 11. Can you take Gabapentin and Tizanidine (Zanaflex®)? There are no reported drug interactions between gabapentin and tizanidine 1. Generally gabapentin and tizanidine combination is safe 12. Can you take Gabapentin and Topiramate (Topamax®)? Gabapentin and topiramate don't interact harmfully with each other. Moreover gabapentin synergistically interacts with topiramate and the combination of both drugs may be useful for refractory partial epilepsy 13. Can you take Gabapentin and Tramadol? There are no drug interactions between gabapentin and tramadol 1. Animal research indicates tramadol-gabapentin combination can interact synergistically and may be effective for the treatment of inflammatory pain 4, 5. Aslo the combination of tramadol plus gabapentin seems to be effective for opioid detoxification15. Can you take Gabapentin and Zolpidem (Ambien®)? Combination of gabapentin and zolpidem is considered safe 1. The pharmacokinetics of gabapentin and zolpidem are unaffected when both medications are taken simultaneously 7. Gabapentin during Pregnancy Pregnancy Category C. Nursing Mothers Gabapentin is excreted in human breast milk. A nursed infant could be exposed to ~1 mg/kg/day of gabapentin. Use in breast-feeding women only if the benefits to the mother outweigh the potential risk to the infant. References:
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