Amoxicillin/Clavulanate potassium (Augmentin®, Co-amoxiclav) Interactions
Amoxicillin/Clavulanate potassium Drug Interactions
Laboratory Test Interactions:
Can you take Co-amoxiclav and Opioid Analgesic at the same time?
There are no reported drug interactions between Amoxicillin/Clavulanate potassium and opioid analgesics. So Co-amoxiclav can be taken safely with hydrocodone, methadone, codeine, tramadol or any other opioid analgesic.
Can you take Co-amoxiclav with Doxycycline?
The manufacturers of some tetracycline antibiotics (including doxycycline) advise that their use with penicillin antibiotics should be avoided2 because of possible antagonistic effect3. However, in practice this interaction is essential only when treating serious infections such as pneumococcal meningitis.
Can you drink alcohol during Co-amoxiclav therapy?
Alcohol does not reduce the effectiveness of Amoxicillin/Clavulanate potassium.
Can you take Co-amoxiclav with food or milk?
The absorption of amoxicillin tends to be decreased by food, but not significantly. However, taking co-amoxiclav with food may reduce the incidence of gastrointestinal side effects. So it would be beneficial to take co-amoxiclav with a meal.
Co-amoxiclav during Pregnancy & Lactation:
Pregnancy Risk Factor: B
Can a person allergic to Penicillin take Co-amoxiclav?
No. Amoxicillin/Clavulanate potassium is contraindicated in patients with a history of allergic reactions to penicillins.