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Azithromycin (Zithromax®, Z-Pak®) Interactions


Azithromycin Drug Interactions

Azithromycin does not form covalent chemical complexes with cytochrome P450 enzymes and does not demonstrate clinically important interactions.

Can you take Azithromycin and Co-trimoxazole (Bactrim®) together?

Azithromycin does not alter the pharmacokinetics of co-trimoxazole.

Can you take Azithromycin and Acetaminophen (Tylenol®) together?

Yes. Azithromycin is often prescribed along with acetaminophen, a fever reducer and pain reliever. There are no potential interactions between these medications.

Can you take Azithromycin with Ibuprofen, Naproxen, or any other NSAID?

Yes. There are no drug interactions between azithromycyn and NSAIDs.

Can you take Azithromycin with Oxycodone, Hydrocodone, or any other opioid analgesic?

Azithromycin does not interfere with opioid analgesics and can be taken with these drugs at the same time.

Is it safe to take Azithromycin with Doxycycline?

There is no negative interaction between azithromycin and doxycycline. So you can take two antibiotics simultaneously if needed.

Is it safe to take Azithromycin with Ciprofloxacin (Cipro®)?

Yes. The combination of azithromycin plus ciprofloxacin has been shown to be safe and possibly synergistic 2.

Can you take Azithromycin with Clindamycin ?

There is no interaction between Azithromycin with Clindamycin.

Can you take Alcohol during Azithromycin treatment?

There are no interactions between alcohol and azithromycin. If you take azithromycin dose in the morning and alcohol consumption will be in the evening, there should not be a problem.

Can you take Azithromycin with food or milk?

Food significantly reduces absorption of azithromycin capsule formulation, but does not alter blood levels of azithromycin tablets or suspension. So you can take azithromycin tablets or suspension without regard to meals. If you are taking azithromycin capsules, you should take the medication on empty stomach.

Azithromycin & Pregnancy

Pregnancy category: B. Azithromycin is generally safe during pregnancy .

References:

  • 1. U.S. Zithromax Prescribing Information PDF
  • 2. Saini H, Chhibber S, Harjai K. Azithromycin and ciprofloxacin: a possible synergistic combination against Pseudomonas aeruginosa biofilm-associated urinary tract infections. Int J Antimicrob Agents. 2015 Apr;45(4):359-67 PubMed

By HealthyStock Research Group, September 2009
Medical resources reviewed: August 2018


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