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Prescription Levaquin (Levofloxacin) Medical Information
Generic Name: Levofloxacin
Common Brand Name: Levaquin
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| Dosage |
Quantity |
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- 4RX.com - International online pharmacy
- Payment methods: VISA
- Delivery: Registered Air Mail, and delivery can take anywhere between 8 and 15 business days.
- Shipping: Shipping fees vary according to the weight of the product. The fee is the same for all countries. The base rate is $16.50 and up. The maximum number per package is 90, so if you order 100 pills 4RX.com will send 2 envelopes and you will need to pay for shipping of 2 parces.
The following product information is not intended to replace the physician's
or manufacturer's instructions.
Levaquin common medical uses:
Levofloxacin is a broad-spectrum antibacterial agent with activity against
a range of Gram-positive, Gram-negative, atypicals and anaerobes.
- Respiratory Tract Infections: community-acquired pneumonia (CAP),
nosocomial pneumonia, acute exacerbations of chronic bronchitis (AECB),
acute sinusitis.
- Genitourinary Tract infections: chronic bacterial prostatitis, uncomplicated
UTI, acute pyelonephritis, complicated UTI
- Complicated skin & skin structure infections
- Uncomplicated skin and skin structure infections
Levaquin dosage:
- Acute Bacterial Exacerbation of Chronic Bronchitis
Adults: 500 mg every 24 h for 7 days.
- Acute Bacterial Sinusitis
Adults: 500 mg every 24 h for 10 to 14 days or 750 mg every 24 h for
5 days.
- Anthrax (inhalational; postexposure)
Adults: 500 mg every 24 h for 60 days.
- Chronic Bacterial Prostatitis
Adults: 500 mg every 24 h for 28 days.
- Community-Acquired Pneumonia
Adults: 500 mg every 24 h for 7 to 14 days; or 750 mg every 24 h for
5 days.
- Complicated Skin and Skin Structure Infections,
Nosocomial Pneumonia
Adults: 750 mg every 24 h for 7 to 14 days.
- Complicated UTIs,
Acute Pyelonephritis
Adults: 250 mg every 24 h for 10 days.
- Uncomplicated Skin and Skin Structure Infections
Adults: 500 mg every 24 h for 7 to 10 days.
- Uncomplicated UTIs
Adults: 250 mg every 24 h for 3 days.
Levaquin side effects:
- Cardiovascular: torsades de pointes, vasodilation (postmarketing).
- CNS: headache (6%); insomnia (5%); dizziness (3%); anxiety,
fatigue (1%); abnormal EEG, encephalopathy (postmarketing).
- Dermatologic: pruritus, rash (1%); erythema multiforme, Stevens-Johnson
syndrome (postmarketing).
- Respiratory: pharyngitis, dyspnea, rhinitis, sinusitis (1%);
allergic pneumonitis (postmarketing).
- Ophthalmic: foreign body sensation, ocular pain or discomfort,
photophobia, transient decreased vision, transient ocular burning (1%
to 3%); lid edema, ocular dryness, ocular itching (less than 1%).
- Gastrointestinal: nausea (7%); diarrhea (6%); constipation
(4%); abdominal pain, vomiting (3%); dyspepsia (2%); flatulence (1%).
- Genitourinary: vaginitis (2%).
- Hematologic: eosinophilia, hemolytic anemia, increased INR/PT
(postmarketing).
- Lab Tests: decreased glucose, decreased lymphocytes (2%).
- Miscellaneous: pain (2%); back pain, chest pain (1%); anaphylactic
shock, anaphylactoid reactions, dysphonia, multisystem organ failure,
peripheral neuropathy, rhabdomyolysis, tendon rupture (postmarketing).
Levaquin precautions:
- Children: Safety and efficacy in pediatric patients and adolescents
less than 18 years of age have not been established.
- Altered cardiac conduction: Fluoroquinolones may prolong QTc
interval; avoid use in patients with a history of QTc prolongation,
uncorrected hypokalemia, hypomagnesemia, or concurrent administration
of other medications known to prolong the QT interval (including Class
Ia and Class III antiarrhythmics, cisapride, erythromycin, antipsychotics,
and tricyclic antidepressants).
- CNS stimulation: Tremor, restlessness, confusion, and very
rarely hallucinations or seizures may occur; use with caution in patients
with known or suspected CNS disorder. Discontinue in patients who experience
significant CNS adverse effects (eg, dizziness, hallucinations, suicidal
ideations or actions).
- Peripheral neuropathy: The use of quinolones has been linked
to peripheral neuropathy (rare); discontinue if symptoms of sensory
or sensorimotor neuropathy occur.
- Tendon inflammation/rupture: There have been reports of tendon
inflammation and/or rupture with quinolone antibiotics; risk may be
increased with concurrent corticosteroids, particularly in the elderly.
Discontinue at first sign of tendon inflammation or pain.
- Renal impairment: Use with caution in patients with renal impairment.
- Seizures: Use with caution in individuals at risk of seizures
(CNS disorders or concurrent therapy with medications which may lower
seizure threshold). Potential for seizures, although very rare, may
be increased with concomitant NSAID therapy.
- Disturbances of blood glucose: Disturbances of blood glucose,
including symptomatic hyper and hypoglycemia, have been reported, usually
in diabetic patients receiving concomitant treatment with an oral hypoglycemic
agent (e.g., glyburide/glibenclamide) or with insulin. In these patients,
careful monitoring of blood glucose is recommended. If a hypoglycemic
reaction occurs in a patient being treated with levofloxacin, discontinue
levofloxacin immediately and appropriate therapy should be initiated.
Levaquin drug interactions
- Corticosteroids: concurrent use may increase the risk of tendon
rupture, particularly in elderly patients (overall incidence rare).
- Glyburide: fluoroquinolones may increase the effect of glyburide
- Antacids, iron salts, sucralfate, zinc salts; didanosine chewable
buffered tablets, multivitamins (oral only): may decrease oral absorption
of levofloxacin. Levofloxacin should be administered 2 hours before
or 2 hours after these agents.
- Antiarrhythmic agents (Class Ia and Class III antiarrhythmics),
erythromycin, cisapride, antipsychotics, and cyclic antidepressants:
increased risk of life-threatening cardiac arrhythmias, including torsades
de pointes. Avoid coadministration with levofloxacin.
- NSAIDs increased risk of CNS stimulation and convulsive seizures.
- Probenecid: decreased renal secretion of levofloxacin.
- Warfarin May increase bleeding.
Test Interactions:
- Some quinolone antibiotics may produce a false-positive urine screening result
for opiates using commercially-available immunoassay kits. This has
been demonstrated most consistently for levofloxacin and ofloxacin,
but other quinolones have shown cross-reactivity in certain assay kits.
Confirmation of positive opiate screens by more specific methods should
be considered.
Pregnancy & Lactation:
Pregnancy Risk Factor: C
Reports of arthropathy (observed in immature animals and reported rarely
in humans) have limited the use of fluoroquinolones in pregnancy. Teratogenic
effects were not observed with levofloxacin in animal studies; however,
decreased body weight and increased fetal mortality were reported. Based
on limited data, quinolones are not expected to be a major human teratogen.
Although quinolone antibiotics should not be used as first-line agents
during pregnancy, when considering treatment for life-threatening infection
and/or prolonged duration of therapy, the potential risk to the fetus
must be balanced against the severity of the potential illness.
Breast-Feeding:
Other fluoroquinolones are known to be excreted in breast milk. Based on data
from ofloxacin, excretion of levofloxacin would be expected. The manufacturer
recommends to discontinue nursing or to discontinue levofloxacin.
Overdose:
Symptoms of overdose include acute renal failure, seizures. Treatment
should include GI decontamination and supportive care; not removed by
peritoneal or hemodialysis.
References:
- 1. U.S. Food and Drug Administration. Levofloxacin (Levaquin) U.S.
Prescribing Information. Available at (PDF format)
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