Doxycycline Hyclate Prescription

Generic Name: Doxycycline Hyclate

Brand Names: Doryx, Doxy, Doxylag, Oracea, Vibramycin, Zadorin

Buy Doxycycline without a prescription

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• No prior prescription required.

Medical uses

Doxycycline Hyclate is a broad-spectrum tetracycline antibiotic. It is used against a wide variety of bacterial infections, including Rocky Mountain spotted fever and other fevers caused by ticks, fleas, and lice; urinary tract infections; trachoma; and some gonococcal infections in adults. It is an approved treatment for inhalational anthrax. Doxycycline is also used to treat severe acne and amoebic dysentery (diarrhea caused by severe parasitic infection of the intestines).

Doxycycline may also be taken for the prevention of malaria on foreign trips of less than 4 months' duration. Occasionally doctors prescribe doxycycline to treat early Lyme disease and to prevent traveler's diarrhea.

Doxycycline in malaria

Malaria is a mosquito-transmitted, life-threatening disease which commonly infects travellers in many tropical and subtropical areas, sometimes fatally. Central and South America and Caribbean, sub-Saharan Africa, Middle East, Indian subcontinent, South-East Asia, and Oceania are considered malaria-risk areas.

Malaria is caused by a blood parasite of the genus Plasmodium, transmitted by the bite of infected female anopheline mosquitoes. Four species of Plasmodium commonly infect humans: P. falciparum, P. vivax, P. ovale, and P. malariae. The most dangerous form of malaria is that due to P. falciparum.

Malaria can be prevented by taking antimalarials. Doxycycline is an effective antimalarial against all four species of Plasmodium and has comparable efficacy to mefloquine (around > 90%). Doxycycline may be used in areas of mefloquine-resistant P. falciparum malaria and in travellers visiting high-risk areas unable to take mefloquine.

For malaria prophylaxis doxycycline should be taken 100 mg daily, beginning 1 to 2 days before travel to the malarial area, and continuing during travel and for 4 weeks after leaving. It can be taken for periods up to six months.

Doxycycline can prevent other infections associated with the travel destination, such as rickettsial infections, Lyme disease, scrub typhus, travellers’ diarrhea, and leptospirosis. So it may be preferred by travellers planning to hike, camp, and swim in fresh water.

A prophylactic course of doxycycline is similar in cost to mefloquine, and much cheaper than atovaquone-proguanil.

Doxycycline dosage:

Adults and children >8 years (>45 kg): The usual dose of doxycycline is 200 mg on the first day of treatment (100 mg every 12 hours) followed by a maintenance dose of 100 mg per day. The maintenance dose may be taken as a single dose or as 50 mg every 12 hours.

For severe infections (particularly chronic urinary tract infection) may be prescribed 100 mg every 12 h.

Children >8 years (< 45 kg): 2-5 mg/kg/day in 1-2 divided doses, not to exceed 200 mg/day.

Brucellosis: 100 mg twice daily for 6 weeks with rifampin or streptomycin.

Chlamydia: 100 mg twice daily for 7 days.

Pneumonia, bronchitis: 100 mg twice daily.

Endometritis, salpingitis, parametritis, or peritonitis: I.V.: 100 mg twice daily with cefoxitin 2 g every 6 hours for 4 days and for 48 hours after patient improves; then continue with oral therapy 100 mg twice daily to complete a 10- to 14-day course of therapy.

Uncomplicated Gonorrhea: 100 mg twice daily for 7 days.

Pelvic inflammatory disease: 100 mg twice daily for 14 days; preceded by a single I.M. dose of cefoxitin or ceftriaxone (CDC, 2010).

Lyme disease, Q fever, or Tularemia: Oral: 100 mg twice daily for 14-21 days.

Periodontitis: 20 mg twice daily as an adjunct following scaling and root planing; may be taken for up to 9 months.

Rickettsial disease, Rocky Mountain spotted fever (RMSF), ehrlichiosis: 100 mg twice daily for 7-14 days or until patient is afebrile for 3 days. Begin promptly since delay can result in fatal consequences.

Rosacea (Oracea only): 40 mg once daily in the morning.

Syphilis: Early syphilis: 100 mg twice daily for 14 days.
Late syphilis: 100 mg twice daily for 28 days.

Yersinia pestis (plague): 100 mg twice daily for 10-14 days.

Vibrio cholerae: 300 mg as a single dose.

Inhalation Anthrax (Post-exposure):
Adults and children (45 kg or more): 100 mg bid for 60 days.
Children (less than 45 kg): 2.2 mg/kg bid for 60 days.

Doxycycline side effects:

• Gastrointestinal: nausea, vomiting, diarrhea, anorexia, glossitis, dysphagia.
• Skin: maculopapular and erythematous rashes; exfoliative dermatitis; photosensitivity.

Rare instances of esophagitis and esophageal ulcerations have been reported.

Precautions:

• Food. While food and milk may decrease GI absorption of doxycycline by up to 20%, administration on an empty stomach is not recommended due to GI intolerance.
• Not recommended in children younger than 8 years of age. Discoloration of teeth and enamel hypoplasia may result.
• Photosensitivity. May cause rash or intensify sunburn in areas exposed to sun or ultraviolet light. Avoid overexposure to sunlight or artificial UV light.
• Espohageal ulceration. Do not take doxycycline just before going to bed. It may not dissolve properly when you are lying down and can irritate your oesophagus.
• Renal toxicity: Rise in BUN has been reported.

Drug interactions

• Antacids (containing aluminum, calcium, or magnesium), calcium or magnesium supplements, products containing iron or zinc - decreased doxycycline absorption and effect; separate by 1 to 2 hours.
• Anticoagulants - increased anticoagulant effect.
• CYP3A4 inducers (carbamazepine, barbiturates, phenytoin) - decreased levels and effect of doxycycline.
• Bile acid sequestrants, Bismuth subsalicylate - decreased doxycycline absorption.
• Methoxyflurane - possible fatal renal toxicity. Avoid concurrent use.
• Oral contraceptives - there is little evidence that tetracyclines reduce the efficacy of the oral contraceptives unless they cause gastrointestinal upset.
• Retinoic acid derivatives - doxycycline may enhance the toxic effect of retinoic acid derivatives. The development of pseudotumor cerebri or benign intracranial hypertension is of particular concern.
• Sodium bicarbonate - greatly reduced doxycycline absorption.

Pregnancy & Lactation:

Pregnancy Risk Factor: D

Exposure to doxycycline during the second or third trimester may cause permanent yellow-gray-brown discoloration of the teeth. Most reports do not show substantial teratogenic risk with the exception of a potential small increased risk for cleft palate or esophageal stenosis.

According to CDC, doxycycline may be warranted in pregnant women with life-threatening illness when suspicion of ehrlichiosis or RMSF is high.

Breast-Feeding: Only minimal amounts of doxycycline are excreted in human milk and the relative amount of tooth staining has been reported to be lower when compared to other tetracyclines. Also, it can disturb the bowel flora.

For short term use, doxycycline is generally considered compatible (low risk to fetus) during breast-feeding.
For chronic use, doxycycline should be used with caution (high risk to fetus) during breast-feeding.

Important to know:

If you have no medical prescription you can still get antibiotic online. However, if your symptoms don't improve after the treatment, you need to consult your doctor to change the prescription.

References:

• 1. U.S. FDA Doxycycline hyclate Prescribing Information