Common medical uses:
Cefuroxime axetil is a cephalosporin antibiotic. Cefuroxime axetil is used for the treatment of infections of lower respiratory tract, urinary tract, skin and skin structures; treatment of uncomplicated gonorrhea, otitis media, pharyngitis, and tonsillitis caused by susceptible strains of specific microorganisms. Treatment of early Lyme disease, pharyngitis/tonsillitis, and impetigo.

Cefuroxime axetil dosage:

For children 3 months to 12 years:

Usual dosage range:
20-30 mg/kg/day in 2 divided doses
Sinusitis, otitis media, and impetigo:
Suspension: 30 mg/kg/day in 2 divided doses for 10 days (maximum dose: 1 g/day)
Tablet: 250 mg twice daily for 10 days
Epiglottitis:
150 mg/kg/day in 3 divided doses for 7-10 days
Pharyngitis/tonsillitis:
Suspension: 20 mg/kg/day (maximum: 500 mg/day) in 2 divided doses for 10 days
Tablet: 125 mg every 12 hours for 10 days

For children from 13 years and adults:

Usual dosage range:
250-500 mg twice daily
Bronchitis (acute and exacerbations of chronic bronchitis):
250-500 mg every 12 hours for 10 days
Gonorrhea:
1 g as a single dose
Lyme disease (early):
500 mg twice daily for 20 days
Pharyngitis/tonsillitis and sinusitis:
250 mg twice daily for 10 days
Skin/skin structure infection (uncomplicated):
250-500 mg every 12 hours for 10 days
Urinary tract infection (uncomplicated):
125-250 mg every 12 hours for 7-10 days

Cefuroxime axetil side effects:

Gastrointestinal: Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis.
Genitourinary: pyuria; renal dysfunction; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy.
Hematologic: eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage.
Hepatic: hepatic dysfunction; abnormal LFT results
Miscellaneous: hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness–like reactions (eg, skin rashes, polyarthritis, arthralgia, fever); phlebitis, thrombophlebitis, and pain at injection site.

Precautions:

Contraindications: Hypersensitivity to cefuroxime, any component of the formulation, or other cephalosporins.

Elevated INR: May be associated with increased INR, especially in nutritionally-deficient patients, prolonged treatment, hepatic or renal disease.
Penicillin allergy: Use with caution in patients with a history of penicillin allergy, especially IgE-mediated reactions (eg, anaphylaxis, angioedema, urticaria).
Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment.
Renal impairment: Use with caution in patients with renal impairment; modify dosage in severe impairment.
Suspension/tablet bioequivalence: Tablets and oral suspension are not bioequivalent; do not substitute on a mg-per-mg basis.

Drug interactions

Antacids: May decrease the effects of oral cefuroxime due to reduced absorption; separate dosing by 2 hours.
H2 antagonists: May decrease the effects of oral cefuroxime due to reduced absorption; separate dosing by 2 hours.
Probenecid: May increase the effects of cefuroxime.
Typhoid vaccine: Antibiotics may decrease the therapeutic effects of typhoid (Ty21a strain) vaccine; vaccination should be delayed >24 hours after administration of antibiotic.

Pregnancy & Lactation:
Pregnancy Risk Factor: B

Animal studies have not shown any teratological effects.

Breast-Feeding:

Theoretically, drug absorbed by nursing infant may change bowel flora or affect fever work-up result.
As a class, cephalosporins are used to treat infections in infants.

Where and How to Buy:
If you would like to order Cefuroxime (Ceftin) with no prescription online, choose the offer from the above price table.

References:

1. U.S. Food and Drug Administration. Cefuroxime axetil (Ceftin) U.S. Prescribing Information. Available at (PDF format): Prescribing Information