Drug Interactions

Amoxicillin/Clavulanate potassium (AugmentinŽ, Co-amoxiclav) Interactions

Amoxicillin/Clavulanate potassium Drug Interactions

  • Allopurinol: Concomitant use of allopurinol and amoxicillin can increase the likelihood of allergic skin reactions.
  • Aminoglycosides: May be synergistic against selected organisms.
  • Methotrexate: Augmentin may increase the exposure to methotrexate during concurrent therapy; monitor.
  • Probenecid: May increase levels of Augmentin; concomitant use not recommended.
  • Warfarin: Effects of warfarin may be increased.

Laboratory Test Interactions:
May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets (enzyme-based tests [eg, Clinistix , Tes-Tape ] are recommended); false-positive direct Coombs test result in certain patient groups; false-positive protein reactions with sulfosalicylic acid and boiling test, acetic acid test, biuret reaction, and nitric acid test (Bromphenol Blue Test , Multi-Stix is recommended).

Can you take Co-amoxiclav and Opioid Analgesic at the same time?

There are no reported drug interactions between Amoxicillin/Clavulanate potassium and opioid analgesics. So Co-amoxiclav can be taken safely with hydrocodone, methadone, codeine, tramadol or any other opioid analgesic.

Can you take Co-amoxiclav with Doxycycline?

The manufacturers of some tetracycline antibiotics (including doxycycline) advise that their use with penicillin antibiotics should be avoided2 because of possible antagonistic effect3. However, in practice this interaction is essential only when treating serious infections such as pneumococcal meningitis.

Can you drink alcohol during Co-amoxiclav therapy?

Alcohol does not reduce the effectiveness of Amoxicillin/Clavulanate potassium.

Can you take Co-amoxiclav with food or milk?

The absorption of amoxicillin tends to be decreased by food, but not significantly. However, taking co-amoxiclav with food may reduce the incidence of gastrointestinal side effects. So it would be beneficial to take co-amoxiclav with a meal.

Co-amoxiclav during Pregnancy & Lactation:

Pregnancy Risk Factor: B
Both Co-amoxiclav components cross the human placenta. Teratogenic effects have not been reported. Use in women with premature rupture of fetal membranes may increase risk of necrotizing enterocolitis in neonates.

Augmentin is excreted in the milk; therefore, caution should be exercised when administered to a nursing woman.

Can a person allergic to Penicillin take Co-amoxiclav?

No. Amoxicillin/Clavulanate potassium is contraindicated in patients with a history of allergic reactions to penicillins.


  • 1. U.S. FDA Augmentin Prescribing Information
  • 2. U.S. FDA Doxycycline Prescribing Information
  • 3. Lepper MH, Dowling HF. Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin: studies including observations on an apparent antagonism between penicillin and aureomycin. Arch Intern Med (1951) 88, 489–94

Last modified: October, 2015

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