Augmentin (Co-amoxiclav)

Generic Name: Amoxicillin/Clavulanic acid

Common Brand Name: Augmentin, Co-amoxiclav

Buying Augmentin (Co-amoxiclav) Without Prescription

• International pharmacy
• Payment methods: VISA
• Delivery: Registered Air Mail, and delivery can take anywhere between 8 and 15 business days. The base rate is $16.50 and up.

Medical uses:
Augmentin is a beta-lactam antibacterial penicillin co-formulated with a beta-lactamase inhibitor. Addition of clavulanic acid in Augmentin enhances the effectiveness of this prescription antibiotic against many bacteria that are ordinarily resistant to amoxicillin.

It is indicated for the treatment of the infections caused by susceptible strains of specific organisms:

• Otitis media
• Sinusitis
• Lower respiratory tract infections
• Skin and skin structure infections
• Urinary tract infections

Augmentin dosage:
Note: Dose is based on the amoxicillin component.

Usual dosage range:

• Infants <3 months: 30 mg/kg/day divided every 12 hours using the 125 mg/5 mL suspension
• Children >=3 months and <40 kg: 20-90 mg/kg/day divided every 8-12 hours
• Children >40 kg and Adults: 250-500 mg every 8 hours or 875 mg every 12 hours

Children >=3 months and <40 kg

• Lower respiratory tract infections, severe infections, sinusitis: 45 mg/kg/day divided every 12 hours or 40 mg/kg/day divided every 8 hours
• Mild-to-moderate infections: 25 mg/kg/day divided every 12 hours or 20 mg/kg/day divided every 8 hours

Children >=16 years and Adults:

• Bite wounds (animal/human): 875 mg every 12 hours or 500 mg every 8 hours
• Chronic obstructive pulmonary disease: 875 mg every 12 hours or 500 mg every 8 hours
• Erysipelas: 875 mg every 12 hours or 500 mg every 8 hours
• Pneumonia (Aspiration): 875 mg every 12 hours
• Pyelonephritis (acute, uncomplicated): 875 mg every 12 hours or 500 mg every 8 hours
• Skin abscess: 875 mg every 12 hours

Augmentin side effects:

• Gastrointestinal: diarrhea/loose stools (9%); nausea (3%); vomiting (1%); abdominal pain or cramps; anorexia; bloody diarrhea; enterocolitis; epigastric distress; flatulence; gastritis; pseudomembranous colitis; rectal bleeding.
• Dermatologic: skin rashes, urticaria (3%); erythema multiforme; maculopapular to exfoliative dermatitis; pruritus; vesicular eruptions.
• Genitourinary: vaginitis (1%); interstitial nephritis (eg, oliguria, proteinuria, hematuria, hyaline casts, pyuria); nephropathy.
• CNS: agitation; anxiety; behavioral changes; confusion; convulsions; dizziness; fatigue; headache; insomnia; reversible hyperactivity.
• EENT: abnormal taste sensation; black hairy tongue; glossitis; itchy eyes; laryngeal edema; laryngospasm; sore or dry mouth or tongue; stomatitis.
• Hematologic: agranulocytosis; anemia; increased basophils; bone marrow depression; eosinophilia; granulocytopenia; hemolytic anemia; increased monocytes; increased or decreased lymphocyte count; leukopenia; neutropenia; increased platelets; prolonged bleeding and prothrombin time; reduced hemoglobin or hematocrit; thrombocytopenia; thrombocytopenic purpura.
• Hepatic: cholestatic jaundice; transient hepatitis.
• Metabolic: reduced albumin; elevated serum alkaline phosphatase and hypernatremia; reduced serum potassium; reduced total proteins and uric acid.
• Miscellaneous: hyperthermia; superinfection.

Precautions:

This antibiotic is contraindicated in patients with a history of allergic reactions to any penicillin. It is also contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with Augmentin.

• Infectious mononucleosis: Ampicillin-class antibiotics should not be administered to patients with mononucleosis.
• Anaphylactoid/hypersensitivity reactions: Serious and occasionally severe or fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy, especially with a history of beta-lactam hypersensitivity, history of sensitivity to multiple allergens, or previous IgE-mediated reactions (eg, anaphylaxis, angioedema, urticaria). Use with caution in asthmatic patients. Low incidence of cross-allergy with cephalosporins exists.
• Diarrhea: Incidence of diarrhea is higher than with amoxicillin alone.
• Hepatic effects: Although rare, hepatic dysfunction is more common in elderly and/or males, and occurs more frequently with prolonged treatment, and may occur after therapy is complete.
• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis.
• Hepatic dysfunction: Use with caution in patients with hepatic impairment.
• Renal dysfunction: Use with caution in patients with renal impairment; dosage adjustment recommended.

Augmentin drug interactions

• Allopurinol: Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.
• Aminoglycosides: May be synergistic against selected organisms.
• Methotrexate: Penicillins may increase the exposure to methotrexate during concurrent therapy; monitor.
• Oral contraceptives: Anecdotal reports suggesting decreased contraceptive efficacy with penicillins have been refuted by more rigorous scientific and clinical data.
• Probenecid: May increase levels of penicillins (amoxicillin); concomitant use not recommended.
• Warfarin: Effects of warfarin may be increased.

Laboratory Test Interactions:
May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets (enzyme-based tests [eg, Clinistix , Tes-Tape ] are recommended); false-positive direct Coombs test result in certain patient groups; false-positive protein reactions with sulfosalicylic acid and boiling test, acetic acid test, biuret reaction, and nitric acid test (Bromphenol Blue Test , Multi-Stix is recommended).

Pregnancy & Lactation:
Pregnancy Risk Factor: B
Both amoxicillin and clavulanate potassium cross the human placenta. Teratogenic effects have not been reported. Use in women with premature rupture of fetal membranes may increase risk of necrotizing enterocolitis in neonates.

Breast-Feeding:
Ampicillin-class antibiotics are excreted in the milk; therefore, caution should be exercised when Augmentin is administered to a nursing woman.

Overdose:
Symptoms of overdose may include abdominal pain, diarrhea, drowsiness, rash, hyperactivity, stomach pain, and vomiting. Interstitial nephritis and/or crystalluria, possibly resulting in renal failure, may occur; hydration and diuresis may be beneficial.

Price:
If you would like to buy Augmentin with no prescription, choose the offer from the above table.

References:

• 1. U.S. Food and Drug Administration. Augmentin U.S. Prescribing Information. Available at (PDF format): Prescribing Information