Acyclovir Prescription

Generic Name: Acyclovir

Brand Name: Zovirax

Buy Acyclovir Without a Prescription

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Buy Generic Zovirax 5 % Cream Without Prescription

Medical Uses:
Acyclovir is used to treat infections caused by herpes viruses: herpes zoster (shingles); herpes infections of the skin, lip and genital; chickenpox. This medication does not cure herpes, but relieves the pain and may make the infection clear faster. Oral Acyclovir decreases the frequency and severity of recurrent sores. But it is used only by people with severe herpes infections.

Topical acyclovir (Zovirax) cream or ointment does not prevent the recurrence of sores but relieves pain and itching if applied when the earliest symptoms first appear. This medicine may be prescribed for other uses.

Dosage

Genital herpes:

Children:
Initial episode (unlabeled use): 40-80 mg/kg/day divided into 3-4 doses for 5-10 days (maximum: 1 g/day)
Chronic suppression (unlabeled use; limited data): 80 mg/kg/day in 3 divided doses (maximum: 1 g/day), re-evaluate after 12 months of treatment

Adults:
Initial episode: 200 mg every 4 hours while awake (5 times/day) for 10 days (per manufacturer's labeling); 400 mg 3 times/day for 5-10 days has also been reported
Recurrence: 200 mg every 4 hours while awake (5 times/day) for 5 days (per manufacturer's labeling; begin at earliest signs of disease); 400 mg 3 times/day for 5 days has also been reported
Chronic suppression: 400 mg twice daily or 200 mg 3-5 times/day, for up to 12 months followed by re-evaluation (per manufacturer's labeling); 400-1200 mg/day in 2-3 divided doses has also been reported

Herpes zoster (shingles):

Adults (immunocompetent): 800 mg every 4 hours (5 times/day) for 7-10 days

Varicella-zoster (chickenpox):

Children >= 2 years and <= 40 kg (immunocompetent): 20 mg/kg/dose (up to 800 mg/dose) 4 times/day for 5 days

Adults and Children >40 kg (immunocompetent): 800 mg/dose 4 times a day for 5 days

Warnings & Precautions

• Renal side effects: Renal failure (sometimes fatal) has been reported. Dehydration, pre-existing renal disease and nephrotoxic drugs increase risk.
• Nephrotoxic drugs: Use with caution in patients receiving other nephrotoxic drugs.
• Thrombocytopenic purpura/hemolytic uremic syndrome has been reported.
• Elderly: Use with caution in the elderly; higher risk for CNS and renal adverse events.
• Children: Safety and efficacy of oral formulations have not been established in children <2 years of age.
• Adequate hydration: Maintain adequate hydration during oral or intravenous acyclovir therapy.

Side Effects:

Oral Tabs

• Central nervous system: malaise (12%); headache (2%);
• Gastrointestinal: nausea (2-5%), vomiting (3%), diarrhea (2- 3%)

Topical Cream

• Dermatologic: mild pain, burning, or stinging (oinment 30%); pruritus (ointment 4%), itching

Parenteral

• Dermatologic: hives (2%), itching (2%), rash (2%)
• Gastrointestinal: nausea/vomiting (7%)
• Hepatic: liver function tests increased (1-2%)
• Local: Inflammation at injection site or phlebitis (9%)
• Renal: BUN increased (5-10%), creatinine increased (5-10%), acute renal failure

Pregnancy & Lactation

Pregnancy Risk Factor: B
Pregnancy Implications. Teratogenic effects were not observed in animal studies. Acyclovir has been shown to cross the human placenta. There are no adequate and well-controlled studies in pregnant women. Results from a pregnancy registry, established in 1984 and closed in 1999, did not find an increase in the number of birth defects with exposure to acyclovir when compared to those expected in the general population. However, due to the small size of the registry and lack of long-term data, the manufacturer recommends using during pregnancy with caution and only when clearly needed.

Lactation. Acyclovir enters breast milk.

Drug Interactions:

• Probenecid: IV acyclovir plasma levels may be increased, and the duration of action prolonged, while the urinary excretion and renal Cl may be reduced.
• Zidovudine: Increased propensity for lethargy.
• Incompatibility: Precipitation may occur with bacteriostatic water. Do not add acyclovir to biologic or colloidal fluids.
• Laboratory Test Interactions: None well documented.

Overdose:
Symptoms of overdose include agitation, seizures, somnolence, confusion, elevated serum creatinine, and renal failure. In the event of overdose, sufficient urine flow must be maintained to avoid drug precipitation within renal tubules. Hemodialysis has resulted in up to 60% reduction in serum acyclovir levels.

Missed Dose:
Take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Effect of Treatment on Primary Genital Herpes [2]

*--Dosage = 200 mg five times daily for 10 days, given within six days of lesion onset. Information from Mertz GJ, Critchlow CW, Benedetti J, Reichman RC, Dolin R, Connor J. Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection. JAMA 1984;252:1147-51.

Price for Purchase:
You can buy antiviral medicines online even if you have no prescription. Prices are provided for generic cream 5% and 200 mg, 400 mg, and 800 mg tablets.

References:

• 1. U.S. Food and Drug Administration. Acyclovir U.S. Prescribing Information. Available at (PDF format): Prescribing Information
• 2. http://www.aafp.org/afp/20000315/1697.html