Acyclovir (Zovirax®) Interactions
Acyclovir Drug Interactions
Acyclovir is NOT metabolized by CYP isoenzymes. So acyclovir has very few drug interactions, that mainly involve altered renal clearance:
Can you take Acyclovir and Diphenhydramine (Benadryl®) together?
Yes, you can. There are no drug interactions between Acyclovir and Benadryl®.
Can you take Acyclovir and Amoxicillin together?
Yes. It is safe to take acyclovir with amoxicillin (a penicillin antibiotic). They don't interact with each other.
Can you take Acyclovir with antibiotics?
Probably you can, because there are no drug interactions between acyclovir and any of the antibiotics (including azithromycin, cephalexin, doxycycline, minocycline, tetracycline, ciprofloxacin, metronidazone, and other).
Can you take Acyclovir with NSAIDs?
No clinically significant interaction appears to occur between acyclovir and NSAIDs, including aspirin, diclofenac, ibuprofen, naproxen, and other NSAIDs.
Can you take Acyclovir with Acetaminophen (Tylenol®)?
Yes, you can. There are no drug interactions between Acyclovir and acetaminophen (a pain reliever).
Valacyclovir, the L-valyl ester prodrug of acyclovir, is converted in the body to acyclovir. There is no drug interaction between the drug and prodrug per se. However taking acyclovir and valacyclovir at therapeutic doses together will increase blood levels of acyclovir.
Can you take Acyclovir and Lysine?
Yes, it is safe to take acyclovir and lysine at the same time.
Can you take Acyclovir and Alcohol together?
Alcohol doesn't affect blood levels of acyclovir and doesn't diminish the effectiveness of the medication.
Can person allergic to penicillin take acyclovir?
Pregnancy & Lactation
Pregnancy Risk Factor: B
Lactation. Acyclovir enters breast milk.
Last modified: October, 2015