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Wellbutrin SR (Bupropion) Facts
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Basic information
- Generic name: Bupropion hydrochloride, sustained
release
- Brand/Trade names: Wellbutrin SR
- Dosages: 150 mg, 200 mg sustained release tablets
- Pharmacologic category: Antidepressant, Norepinephrine
and Dopamine Reuptake Inhibitor
- FDA approved: October 4, 1996
- Manufacturer: GlaxoSmithKline
- Habit forming? No
- Pregnancy risk factor:
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Medical uses
Wellbutrin SR (Bupropion hydrochloride Sustained-Release) is
an antidepressant (mood elevator), is used to treat depression.
Wellbutrin SR is used to relieve symptoms of depression such as
feelings of sadness, worthlessness or guilt, loss of interest
in daily activities, changes in appetite, tiredness, sleeping
too much, insomnia, and thoughts of death or suicide. This medication
is typically prescribed for depression when selective serotonin
reuptake inhibitors (SSRIs) or tricyclic antidepressants (TCAs)
are not able to be used or are not effective.
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Pharmacological characteristics
- Elimination half-life:
- Metabolism:
- Excretion:
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Benefits
- effective and safe as SSRIs
- fewer and less sever side effects
- not associated with weight gain or sexual dysfunction
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Concerns
- should not be used in people with, or at risk for, a seizure
disorder
- can cause agitation, anxiety, and insomnia
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Unlabeled uses
- weight loss
- bipolar depression
- fibromyalgia
- headaches
- irritable bowel syndrome (IBS)
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Mechanism of action
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Wellbutrin (Bupropion) Discussion Boards &
Forums
- Wellbutrin - generic vs. brand name: http://www.drugs.com/forum/drug-information/index3.html
- Wellbutrin long term effects, What are they? http://www.crazyboards.org/forums/index.php?showtopic=16158
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References
- 1. U.S. Food and Drug Administration. Wellbutrin SR (Bupropion)
U.S. Prescribing Information. Available at (PDF format): Prescribing
Information
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Interesting Wellbutrin SR facts
- GlaxoSmithKline developed a sustained-release (SR) version of
Wellbutrin which releases bupropion at a slower rate.
- The SR formulation is taken twice a day, in order to further decrease
the possibility of adverse side effects and seizures.
- Wellbutrin SR is as effective and safe as SSRIs but may have fewer
and less severe side effects.
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