Tretinoin (all-trans Retinoic acid) is a derivative of vitamin A. Retin-A® is licensed for acne. Renova® is is the only tretinoin cream approved by the FDA for treating sun-damaged skin. The US FDA has not granted approval for Retin-A® brand as an anti-aging remedy.
Topical tretinoin formulations are used for:
Retin-A (Tretinoin) for Wrinkles
The rejuvenation of aging skin is a cherished desire of many people. Wrinkles are caused by the natural aging process, sun damage and the attack of free radicals on the skin.
Retinoids such as tretinoin (Retin-A, Renova) are proven to reduce the wrinkles, discoloration due to sun damage, skin roughness, and pigmentation - and thus slow the aging process of the skin. There is evidence that tretinoin also plays a role in the prevention of aging6.
How does Retin-A work?
Noticeable improvement is seen after 3-4 months of topical application7. It will slowly regress once tretinoin is discontinued. The disappearance of hyperpigmentation takes 1 year until it becomes noticeable.
The beneficial anti-aging effect of tretinoin is due to an increase in dermal collagen. Tretinoin stimulates the new collagen synthesis and an inhibition of enzymes responsible for collagen degradation, and boosts epidermal growth resulting in a thicker epidermis. Tretinoin stimulates production of hyaluronic acid and perhaps other glycosaminoglycans in the dermis. It can also protect against UV-induced collagen destruction and thus prevent photodamage.
Renova® vs Retin A®
What is the same?
Both Renova and Retin-A contain an active ingredient tretinoin, a vitamin A metabolite that occurs naturally in the body.
What is different?
Renova contains tretinoin in a more moisturizing base aimed for mature and dry skin. If you read the PDR, you will find that Retin A is not FDA approved as an anti-aging remedy, but Renova is.
So, Retin A tends to dry out the skin more, which is beneficial to youthful, oily, acne-prone skin, while Renova tends to have a moisturizing effect, which is beneficial for dry, mature skin. Heavy moisturizing base in Renova may cause a flare of acne in teenagers prone to this condition.
Difference between Retinol and Retinoic acid (Tretinoin)
Retinol (vitamin A alcohol), retinal (aldehyde), and retinoic acid all are the forms of vitamin A.
Retinol, a parent form of vitamin A, must be converted into retinaldehyde, and then retinaldehyde into all-trans retinoic acid to become active in the epidermis. Retinol approximately 20 times less potent than retinoic acid.
Retinol is not considered to be a drug. So, retinol-containing cosmetic products are sold over-the-counter.
Retinoic acid (tretinoin), the active metabolite of vitamin A, is classified as a prescription drug.
Retin-A Micro (tretinoin microsphere gel) utilizes a new delivery system, which may minimize its irritative effects. This delivery system works by entrapping tretinoin in sponge-like polymeric microspheres that bring the medication more directly to the follicle and serve as reservoirs.
Mechanism of action
Tretinoin (vitamin A derivative) initiates a series of events that can both prevent and repair photodamage. It increases epidermal and granular layer thickness, decreases epidermal melanin content, and promotes stratum corneum compaction.
Tretinoin downregulates production of enzymes that degrade collagen and, thus, preserves dermal collagen. In addition, when collagen damage has already occurred, tretinoin induces procollagen gene expression.
User Reviews and Ratings
Written by HealthyStock.net, October 2009.